Mo' Mezcal, Mo' Problems

253 Broome St, New York, NY 10002 (map)

So, you've sampled all of this sexy Lower East Side restaurant's 50 different tequilas and you're looking for something new. Try a shot of six different mezcals, including the super high-end Maguey de Pechuga (at an astronomical $26 per shot) or the more popular, and significantly less expensive, Los Amantes Reposado.

50 Carmine St, New York, NY 10014 (map)

Sure, you can sample one of the 11 different mezcals (including the upscale Tobala, made solely from agave plants that are shade-grown high in the mountains), but you might want to ease into mezcal by starting with the Sandia--a refreshing cocktail made from mezcal, Campari, lime and fresh watermelon juice.

433 E 6th St, New York, NY 10009 (map)

No matter how obscure the liquor, Death & Co. probably has a specialty cocktail made with it. In this case, it's the Oaxaca Old Fashioned, which is basically an Old Fashioned (Angostura bitters, flamed orange twist) with El Tesoro Reposado Tequila and Los Amantes Joven Mezcal in lieu of bourbon and agave nectar instead of simple syrup.

157 E Houston St, New York, NY 10002 (map)

Margaritas? Please. When the weather gets warm, true cocktail enthusiasts stop by this bustling Lower East Side spot for the Aguacate and Mezcal, a frozen treat made with an epic list of ingredients: honey, avocado, agave nectar, Midori, Cointreau, lime juice and Scorpion Mezcal from Oaxaca.

311 W 17th St, New York, NY 10011 (map)

Chef/owner Sue Torres takes mezcal seriously at her Chelsea restaurant, serving up nine different single-village varieties, plus a fun little concoction dubbed the Suzy Smokin' Margarita, featuring Gran Centenario Silver tequila, Grand Marnier, fresh lime juice and Del Maguey Chichicapa mezcal.